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TopMolecular Enzymology
November 2008
Papers Selected by Nigel Scrutton
Modern enzymology research is interdisciplinary and endeavours to elucidate the relationship between structure, dynamics and chemistry and relate this to metabolic activity within the cell. The aim is to elucidate, at various levels, mechanistic details of biomolecular processes, ranging from complex multi-component pathways and complexes to single proteins (enzymes), either through ensemble measurements, or at the level of isolated (single) molecules. It is an established but rapidly evolving field, uniting structural and computational approaches with analysis of reaction dynamics, engineering, spectroscopy, chemical analysis and theory. Historically, FEBS Journal has encouraged the submission of high quality papers in the field of enzymology and is particularly keen to publish work that reflects the strong interdisciplinary basis of the field. This selection of recent papers reflects this aim and underscores the high quality work published by FEBS Journal in the field of enzymology.
Structure-guided alteration of coenzyme specificity of formate dehydrogenase by saturation mutagenesis to enable efficient utilization of NADP+.
Aggliki Andreadeli,
Dimitris Platis,
Vladimir Tishkov,
Vladimir Popov,
Nikolaos Labrou
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage: crystal structure and biochemical studies.
B. S. Bhavani,
V. Rajaram,
Shveta Bisht,
Purnima Kaul,
V. Prakash,
M. R. N. Murthy,
N. Appaji Rao,
H. S. Savithri
Hexameric Ring Structure of the N-terminal Domain of Mycobacterium tuberculosis DnaB Helicase
Tapan Biswas,
Oleg Tsodikov
Inter-Flavin Electron Transfer in Cytochrome P450 Reductase: Effects of Solvent and pH Identify Hidden Complexity in Mechanism.
Sibylle Brenner,
Sam Hay,
Andrew Munro,
Nigel Scrutton
An intermediate step in the evolution of ATPases: a hybrid FO-VO rotor in a bacterial Na+ F1FO ATP synthase
Michael Fritz,
Adriana Klyszejko,
Nina Morgner,
Janet Vonck,
Bernd Brutschy,
Daniel Muller,
Thomas Meier,
Volker Muller
Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process
Jianfeng Jin,
Hortense Mazon,
Robert H.H. van den Heuvel,
Dick B. Janssen,
Albert J. Heck,
Marco Fraaije
A cysteine residue near the propionate side-chain of heme is the radical site in ascorbate peroxidase
Sakhito Kitajima,
Miyo Kurioka,
Tadashi Yoshimoto,
Mayumi Shindo,
Kenji Kanaori,
Kunihiko Tajima,
Kenji Oda
Characterization of mutations in crucial residues around the Qo binding site of the cytochrome bc1 complex from Paracoccus denitrificans
Thomas Kleinschroth,
Oliver Anderka,
Michaela Ritter,
Andreas Stockera,
Thomas A. Link,
Bernd Ludwig,
Petra Hellwig
Directed evolution of a histone acetyltransferase - enhancing thermostability, whilst maintaining catalytic activity and substrate specificity
Hans Leemhuis,
Karl P. Nightingale,
F Hollfelder
Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica-polymerase and silica-esterase)
Werner Muller,
Ute Schlobmacher,
Xiaohung Wang,
Alexandra Boreiko,
David Brandt,
Stephan Wolf,
Wolfgang Tremal,
Heinz Schroder
Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli
Meina Neumann,
Silke Leimkühler
Influence of modulated structural dynamics on the kinetics of a-chymotrypsin catalysis. Insights through chemical glycosylation, molecular dynamics, and domain motion analysis
Ricardo J. Sola,
Kai Griebenow
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from mycobacterium tuberculosis
Ekaterina Morganova,
Boris Illarionov,
Thota Sambaiah,
Ilka Haase,
Adelbert Bacher,
Mark Cushman,
Markus Fischer,
rudolf Ladenstein
Reactivity of the Heme-Dioxygen complex of the Inducible Nitric Oxide Synthase in the presence of alternative substrates
David Lefevre-Groboillot,
Jean-Luc Boucher,
Daniel Mansuy,
Dennis Stuehr
Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme
Hans Eklund,
Urszula Kosinska ,
Cecilia Carnrot,
Staffan Eriksson,
Liya Wang
ATP-dependent ligases in trypanothione biosynthesis: Kinetics of catalysis and inhibition by phosphinic acid pseudopeptides
Sandra L. Oza,
Shoujun Chen,
Susan Wyllie,
James K. Coward,
Alan Fairlamb
Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity
Gernot Rauch,
Heidemarie Ehammer,
Stephen Bornemann,
Peter Macheroux
Kinetic characterization of methionine [gamma]-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis
Dan Sato,
Wataru Yamagata,
Shigeharu Harada,
Tomoyoshi Nozaki
The role of group bulkiness in the catalytic activity of psychrophile cold-active protein tyrosine phosphatase
Hiroki Tsuruta ,
Bunzo Mikami,
Chiaki Yamamoto,
Hiroshi Yamagata
Spectroscopic Characterization of Oxyferrous Complex of Prostacyclin Synthase in Solution and in Trapped Sol-Gel Matrix
Hui-Chun Yeh,
Pei-Yung Hsu,
Ah-Lim Tsai,
Lee-Ho Wang
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